Imagerie et radiothérapie
Pr. Nicolas Noiret
I joigned in 1992 the Laboratory of Chemistry of Biomolecules and Organized Systems (UMR CNRS 6226).
I have been working for the last years in various subjects concerning organic and organometallic chemistry, giving me the opportunities to be interested in a broad range of areas
chemistry, physico-chemistry, radiochemistry, biochemistry and medicine.
Applications in organic synthesis concern the preparation of unnatural lipids, amphiphiles and ligands, and, more recently, the depolymerization of EPS, with, most of the time, the
aim of understanding of the relations between the structure and the properties of our molecules for a given application, and to use this knowledge to optimally design new targets.
Applications in organometallic synthesis are focused on the design and the preparation of new technetium and rhenium complexes for imaging and therapy. Our aims are
to develop new cores to stabilize the metals, to connect radioactivities to various vectors and to develop new tools for applications in nuclear medicine. For instance, those vectors
can be Lipiodol, nanocapsules, nanoparticles, C60, antibodies, peptides, …
These researchs led to more than sixty papers in journals with referees, seven patents (including two WO patents) and twelve PhD Thesis (as Director or co-Director). I was
promoted to the HDR (Hability to Direct Research) level in january 2000. Especially for radiopharmaceuticals, my works imply numerous collaborations with public institutions
(Regional Center against Cancer Eugène Marquisof Rennes, ERIT 0104 Angers, U440 Inserm Nantes, Universities of Padova and Ferrara) and industrial companies (Cis-Bio
International Schering, Chelatec).